The number of days and direction is very much depenant upon fitness and personal preferences.
The C2C has been completed in one day, but this is reserved for the super fit. The same would apply to a two day period.
The most demanding part of the Coast to Coast cycle route is the Pennines with the highest point and five big climbs, notably Hartside and Garrigill. Careful consideration should be given to the time required for this part of the route.
A four cycling day period allows the more difficult Pennines region to be split into two days.
End of day 1 in the Keswick area.
End of day 2 in the Pennines.
End of day three in the Consett area.
End of day four at the finish.
A three cycling day period over a long weekend is achievable, but do not understimate the phyical effort requuired, especially in the Pennines.
The following is simply a suggested format using a similar daily mileage.
Check in to a B&B in the area around the start.
Cycling Day 1 - cycle to the Penrith area, or just beyond. Stay at B&B
Cycling Day 2 - cycling in the Pennnines. Stay at B&B. Stanhope is on the eastern edge of the Pennines and with the exception of one hill leaves an easy final day.
Cycling Day 3 - cycle to the end. Depending upon what remains of the Pennines an easy day.
Low Moresby - 3 miles
Distington - 5 miles
Cleator Moor - 5 miles
Keswick - 31 miles
Threlkeld - 35 miles
Troutbeck - 41 miles
Greystoke - 48 miles
Penrith - 55 miles
Clifton - 4 miles from Penrith
Lazonby - 63 miles
Alston - 75 miles
Garrigill - 77 miles
Nenthead - 80 miles
Allenheads - 86 miles
Cowshill - 4 miles from Allenheads,
Rookhope - 92 miles
Eastgate - 95 miles
Stanhope - 97 miles
Castleside - 109 miles
Consett - 111 miles
Newcastle - 128 miles.
Sunderland - 135 miles
Tynemouth - 140 miles